Friday, May 27, 2005
Its a Friday Lightning Round!
Its a Friday Ligtning Round, here we go:
The past few days have been beautiful up here in Michigan. I actually brought out the ole bike (that I bought last year and never used) and put some miles on it Wednesday.
On that note: the Lansing River Trail is a pretty neat bike ride.
I have been putting in some serious hours with a major redesign of my website. Go check it out and tell me what you think.
I think the administration at Michigan State University could improve their bureaucracy by taking a few notes from the old communist Russia (more on that later).
The Biotech world: Now is the time to be buying Biogen-Idec stock. I believe the price has absorbed all of the effects of the Tysabri incident. It is a definite buy to me but please don't just rely on me for your stock buying advice.
I still wouldn't go near Elan, though, its just too risky. At least Biogen is already profitable.
The stock price for Able labs is back up to ~$5/share from its low of $3.5/share - Why????? This company is done, stick a fork in them.
The Plant Made Pharmaceutical World: LSBC is looking at being delisted from the Nasdaq NM to the Nasdaq SC.
Hopefully this next week I can get around to compiling a list of all the field release permits that were granted to the PMPers this year.
My miscellaneous link for the day is Fold@Home. This is a distributed computing projected that uses your computers spare resources to solve protein structures.
Tuesday, May 24, 2005
Why are there no bloggers in the biotech industry?
I was looking through blogger.com today looking for other blogs that had a biotech flavor to them. Unfortunately, I did not come up with anything substantial. The majority of blogs that I have seen out there in cyberspace seems to focus only on internet stuff (search engines, computer technology, etc. . .). What sites there are that aren't filled with computer jargon is filled with the ramblings of lunatics, goths, weirdos, and "artists (painters, poets, writers, etc. . .). Question is, which of these two categories does my blog fit into. OK, fair enough, I'll take the designation as a rambling lunatic.
So whats new in the Biotech industry?
The vultures seem to be circling Able Labs, I count at least five law firms filing class action lawsuits according to their finance page at Yahoo!. I don't know what is worse, the implosion of the company or the vulture lawyers gathering over the fresh roadkill.
Well, I couldn't stand it today, I had to sell my Genentech stock. With its announcement of positive data for Lucentis (a treatment for blindness), the 5% jump in stock price officially made it overvalued. I think it'll dip back at least to $55/60 per share, I may jump back in then. I remember the analysts were screaming that it was overvalued at $50. Here we are at a price 60% above that, oh well, that just goes to show how much you should trust stock market analysts.
Well, its supper time, maybe I'll write a little more afterwards.
Monday, May 23, 2005
The Able labs "blowup"
Sunday, May 22, 2005
A country boy can survive
I've mentioned that I am an advisor for the Michigan State Farmhouse Chapter. Most of you probably don't know who or what Farmhouse is. Farmhouse is an international fraternity that is open to all majors. Most of the members come from a rural background. Many Farmhouse chapters are at the top of the grade rankings on their campus. You're first impression is that it is a bunch of uncultured rednecks sitting around discussing what brand of tractor is the best between their classes on how to grow hogs. Well, you are probably half correct. There have been many heated discussions about which brand of tractor is the best and there are several guys who are studying how to grow hogs. But there is much more going on behind the doors at 151 Bogue Street. As I am writing this entry, I am sitting in the front apartment of the chapter house, using a wireless connection to the internet. Yes, I said a wireless connection to the internet. And it was set up by one of the members in the house. There are currently three graduate students who live in or frequent Farmhouse. On of them being Nick Tipper, a Masters student in Agricultural Engineering. With his help, this house is wired with a DSL internet connection in each room and is covered by wireless internet service. Therefore, if you happen to drive by the house and see a couple of guys sitting on the front porch with their laptops in front of them, they are probably getting some serious work done while being able to enjoy the outdoors. On the whole, the use of science in agriculture has grown. Most good animals herds are bred via artificial insemination based on several selection criteria. The use of herbicides in agriculture is a major environmental issue and new technolgies are being used to selectively apply herbicides and fertilizers to those parts of the crop that need them the most. No, agriculture isn't like it used to be where you could make a decent living off the land with an eigth grade education. To be able to survive as a farmer these days, you've got to really know the science behind the things you are growing. You would think that a biochemist such as I would stick out like a sore thumb amongst this group of guys but I don't. So the next time you think of Farmhouse, or farmers in general, I hope you realize the intelligence being used to put food on your plate. And thanks again to Nick Tipper and the gang for getting the wireless internet up and going so I can publish this from by PDA sitting on the front porch of Farmhouse.
An introduction to the Plant Made Pharmaceutical Industry
Ah the plant made pharmaceutical industry (and no, I'm not talking about that stuff grown hydroponically in someones apartment behind tin-foiled windows). PMPs (plant made pharmaceuticals) are enzymes or antibodies made by recombinantly expressing proteins in plants. Such proteins are traditionally made in cell cultures (e. coli, chinese hamster ovary, yeast, etc. . .). However, production using these cell cultures can be very expensive, scale up of production requires massive amounts of capital, and contamination with other microbes of the cell culture is a major concern. With a plant based production system, scale up does not require as much capital, you can simply plant more acreage. Contamination is not an issue as the plants native resistance strategies are used. All-in-all, it has been estimated that a plant based expression system for the production of a drug can decrease the cost for the manufacture of that compound by about tenfold. Over the course of a couple of blogs, I will delve into the details of the plant-made pharmaceutical industry and give you my opinions as to where the industry may be heading. If you want to do a little research on your own, I would suggest MolecularFarming.com. I want to now give you a little background into my qualifications to be able to give valued opinions about this industry. I was an employee at Large Scale Biology for almost three years. I chose to leave the company two years ago because I felt that my career was not advancing fast enough. For anyone that has followed LSBC, you will know that the company hasn't really gone anywhere in a couple of years although they have surprised me by being able to keep their doors open for business. I still believe I made the right choice by leaving the company as my level of understanding of biochemistry and molecular biology has increased greatly and I have been able to really study the PMP industry using my newfound knowledge for a couple of years. Well, that's about enough for this installment. If you're looking for a little lighter of a read, try Fark.com
Friday, May 20
Got to say it was a nice day up here in Michigan. Of course, I've had to spend it all day in the lab massaging some microarray data. If you ever want to see a process that vomits more data than anything I've ever seen, then analyze a few microarray slides. I guess I really need to brush up on my computer science and statistics.
Wow, its kind of been a quite day here in the lab, I've got something accomplished this week, and it looks like I'm headed for a pretty uneventful weekend. Compared to the last 7 or 8 months, this week was kind of unique.
In my last post, I gave you the following to chew on:
> Something to think about: > Bioinformatics - how much information will become available (number of > genomes for unique species, proteomes, etc) in the next 10 years and > how will it be processed?
Well, I'm going to let you chew on that for a while and give you another assignment. I want you to start brushing up on your knowledge of the Plant Made Pharmaceutical Industry. I'm going to fire a few salvo's that way soon so you are warned.
Friday, May 20, 2005
Well, I guess I've named my blog. What is common sense to a biochemist? I may attempt to answer that question someday but not today. Think it over for yourself. Anyways, if you want to find out more about me, please visit my website. It's a little out of date but now with summertime rolling around maybe I can get back to fixing it up. I don't know if you could call me a "biochemist" by trade, I like to think of myself more as a "protein scientist" (alright, so that's probably just some asinine symantics there). I am currently a graduate student at Michigan State University working towards a Ph.D. in Biochemistry and Molecular Biology. As far as this blog goes, I really don't know to much of the direction it will take. I'll probably throw in my thoughts on such things as the Plant Made Pharmaceuticals Industry and the Pharmaceutical industry in general since that is what I know. I can be pretty opinionated so expect some rants on various current issues. I might even throw in a few war stories from my time involved as a member and advisor for a couple of Farmhouse fraternity chapters. This blog is syndicated so you can read it via your newsreader or however that works. I don't know much about syndication yet, but it is on my list of things to get around to learning about. -- Brian Barnett Graduate Assistant Michigan State University
Tuesday, May 17, 2005
Just testing out the e-mail capabilities of this blog
Just testing out the e-mail capabilities of this blog. -- Brian Barnett Graduate Assistant Michigan State University